Skin microbiome influences outcome of infection

  The make up of the bacterial community on the skin influences whether subjects developed pustules after intentional inoculation or whether the infection resolved itself. These results suggest that at baseline, resolvers and pustule formers have distinct skin bacterial communities which change in response to infection and the resultant immune response. OPEN ACCESS paper The…

Skin Stores Up Salt

This paper reports on a population of skin cells that stores excess salt and play a role in the control of blood pressure and sodium balance. http://www.jci.org/articles/view/60113 Immune cells control skin lymphatic electrolyte homeostasis and blood pressure The skin interstitium sequesters excess Na+ and Cl– in salt-sensitive hypertension. Mononuclear phagocyte system (MPS) cells are recruited…

Phage Therapy for Problem Skin?

http://mbio.asm.org/content/3/5/e00279-12 Propionibacterium acnes Bacteriophages Display Limited Genetic Diversity and Broad Killing Activity against Bacterial Skin Isolates ABSTRACT Investigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial inhabitant, Propionibacterium acnes, which…