mtDNA deletions and age-related muscle loss

    Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age With age, somatically derived mitochondrial DNA (mtDNA) deletion mutations arise in many tissues and species. In skeletal muscle, deletion mutations clonally accumulate along the length of individual fibers. At high intrafiber abundances, these mutations disrupt individual cell respiration and are linked…

Muscle Adaptations with Endurance and Resistance Training

Good overview and some information that might result in a change in exercise regimen. Nutrition & Metabolism 2015 12:59 DOI: 10.1186/s12986-015-0055-9 Glycogen availability and skeletal muscle adaptations with endurance and resistance exercise It is well established that glycogen depletion affects endurance exercise performance negatively. Moreover, numerous studies have demonstrated that post-exercise carbohydrate ingestion improves exercise recovery by…

Dietary Eicosapentaenoic acid restores Mitochondria in Old Mice

It might be too soon to start popping Eicosapentaenoic acid supplements to boost aging muscles; still the findings are intriguing. Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice Mitochondrial dysfunction is often observed in aging skeletal muscle and is implicated in age-related declines in physical function. Early evidence…

Mixing Strength and Endurance Training

Mixing endurance and strength training is difficult, but there are things one can do to maximize the results. OPEN ACCESS Using Molecular Biology to Maximize Concurrent Training Very few sports use only endurance or strength. Outside of running long distances on a flat surface and power-lifting, practically all sports require some combination of endurance and…

Transcriptome Differences in Male and Female Muscle

Men have muscle. Women have muscle. Muscle tissue looks the same and so do muscle cells; but are they really? This study looked at the human muscle transcriptome, the subset of the genome that is transcribed, and found some key differences in gene expression and gene activity. The human skeletal muscle transcriptome: sex differences, alternative…

Protein Intake – Not Just How Much but also When

Eating small portions of protein through the day will maximize net balance. OPEN ACCESS Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males Background The pattern of protein intake following exercise may impact whole-body protein turnover and net protein retention. We determined the effects of different protein feeding strategies on protein…