C.difficile move in when Bacteroides, Lachnospiraceae, and Ruminococcaceae move out

It’s hard to move into a house that is already occupied. Clostridium difficile infections are a little like that; this study found absence of certain types of bacteria is associated with colonization. Microbiome Data Distinguish Patients with Clostridium difficile Infection and Non-C. difficile-Associated Diarrhea from Healthy Controls The gut microbiome, composed of the trillions of…

Exercise changes gut microbiota

More microbiome news. This one reports gut microbioata profiles change in response to exercise. Free access   Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats Background Obesity is a multifactor disease associated with cardiovascular disorders such as hypertension. Recently, gut microbiota was linked to obesity pathogenesisand shown to influence the host…

Microbiome, Probiotics and Diabetes

  Open access. Gut microbiota, probiotics and diabetes >Diabetes is a condition of multifactorial origin, involving several molecular mechanisms related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1,…

Bacteria Influence Cholesterol Conversion

Like the discoveries with genomics, microbiomics has already proven to be incredibly productive and many of those discoveries have been noted in this blog. In this new paper Swedish researcher report that bacteria play a role in cholesterol metabolism. They find that gut bacteria produce FXR antagonists which eventually leads to reduced clearance of bile…

Human Breast Milk Contains Over 700 Types of Bacteria

Spanish led team of researchers finds more than 700 different species of bacteria in breast milk. Among the other findings: over-weight mothers and mothers who elected for caesarean births had lower bacterial diversity than mothers who had vaginal births or unplanned caesareans. http://www.ncbi.nlm.nih.gov/pubmed/22836031 Am J Clin Nutr. 2012 Sep;96(3):544-51. doi: 10.3945/ajcn.112.037382. Epub 2012 Jul 25.…

Mibrobiome of Ancient Human Poop is More Like Rural than Urban Poop

  Using 8000, 1600 and 1400 year old coprolite samples the authors find that ancient samples more closely resemble those found in rural communities than those of urban communities. OPEN ACCESS http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0051146 Insights from Characterizing Extinct Human Gut Microbiomes In an effort to better understand the ancestral state of the human distal gut microbiome, we…

Phage Therapy for Problem Skin?

http://mbio.asm.org/content/3/5/e00279-12 Propionibacterium acnes Bacteriophages Display Limited Genetic Diversity and Broad Killing Activity against Bacterial Skin Isolates ABSTRACT Investigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial inhabitant, Propionibacterium acnes, which…