Skin microbiome influences outcome of infection

  The make up of the bacterial community on the skin influences whether subjects developed pustules after intentional inoculation or whether the infection resolved itself. These results suggest that at baseline, resolvers and pustule formers have distinct skin bacterial communities which change in response to infection and the resultant immune response. OPEN ACCESS paper The…

C.difficile move in when Bacteroides, Lachnospiraceae, and Ruminococcaceae move out

It’s hard to move into a house that is already occupied. Clostridium difficile infections are a little like that; this study found absence of certain types of bacteria is associated with colonization. Microbiome Data Distinguish Patients with Clostridium difficile Infection and Non-C. difficile-Associated Diarrhea from Healthy Controls The gut microbiome, composed of the trillions of…

Exercise changes gut microbiota

More microbiome news. This one reports gut microbioata profiles change in response to exercise. Free access   Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats Background Obesity is a multifactor disease associated with cardiovascular disorders such as hypertension. Recently, gut microbiota was linked to obesity pathogenesisand shown to influence the host…

Microbiome, Probiotics and Diabetes

  Open access. Gut microbiota, probiotics and diabetes >Diabetes is a condition of multifactorial origin, involving several molecular mechanisms related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1,…

Microbiome Modifies Colon Cancer Growth

  A fascinating link between gut microbiome, colon cancer and how manipulating gut bacterial profiles affects tumorigenesis. The Gut Microbiome Modulates Colon Tumorigenesis IMPORTANCE  The trillions of bacteria that live in the gut, known collectively as the gut microbiome, are important for normal functioning of the intestine. There is now growing evidence that disruptive changes…

Breast Milk Also Provides Good Gut Bacteria

Mother’s milk is the source of an infant’s gut bacteria. Given the role of good bacteria in the development of immunity and digestive health, it appears that ‘breast’ really is best. http://onlinelibrary.wiley.com/doi/10.1111/1462-2920.12238/abstract Vertical mother–neonate transfer of maternal gut bacteria via breastfeeding Babies Breast milk has recently been recognized as source of commensal and potential probiotic bacteria.…

“The Enemy of My Enemy” Goes Microbial

In an opinion piece published on the ASM’s open access journal, Eric T. Harvill suggests we should get to know the enemy of our enemy (pathogens). Easy to read, free of technical jargon and very interesting. To understand how this approach might work in practice read the NEJM’s blog : Doctors Turned Ecologists: Infusion of…

Bacteria Influence Cholesterol Conversion

Like the discoveries with genomics, microbiomics has already proven to be incredibly productive and many of those discoveries have been noted in this blog. In this new paper Swedish researcher report that bacteria play a role in cholesterol metabolism. They find that gut bacteria produce FXR antagonists which eventually leads to reduced clearance of bile…

Bacteria, Ancient Teeth and Modern Teeth

I had previously noted research indicating that modern diet has changed the bacterial profile of our guts. This new paper looks at the oral microbiome at different time periods and how that has affected dental health. Like the previous paper it finds a marked change in the microbiomes between ancient and modern samples specifically tied…