Skin microbiome influences outcome of infection

  The make up of the bacterial community on the skin influences whether subjects developed pustules after intentional inoculation or whether the infection resolved itself. These results suggest that at baseline, resolvers and pustule formers have distinct skin bacterial communities which change in response to infection and the resultant immune response. OPEN ACCESS paper The…

Urinary Tract Infection: Pee Perturbs Pili Production

Human urine interferes with pili and inhibits E.coli attachment to bladder. Human Urine Decreases Function and Expression of Type 1 Pili in Uropathogenic Escherichia coli IMPORTANCE Urinary tract infections (UTIs) are extremely common infections, frequently caused by uropathogenic Escherichia coli (UPEC), that are treated with antibiotics but often recur. Therefore, UTI treatment both is complicated by…

C.difficile move in when Bacteroides, Lachnospiraceae, and Ruminococcaceae move out

It’s hard to move into a house that is already occupied. Clostridium difficile infections are a little like that; this study found absence of certain types of bacteria is associated with colonization. Microbiome Data Distinguish Patients with Clostridium difficile Infection and Non-C. difficile-Associated Diarrhea from Healthy Controls The gut microbiome, composed of the trillions of…

Poop-freezies to treat Clostridium difficile Infection

The use of frozen fecal samples for the treatment of C.difficile infection showed a high success rate in this study. Up or down – nasogastric or colonoscopy inoculation – both were effective., 70% after single treatment which went up to 90% on re-treatment. See also last year’s “The Enemy of My Enemy” Goes Microbial  …

C. difficile spores stick to hands of healthcare workers

A quarter of health-care workers’s hands are contaminated with C.difficile spore contamination after caring for C.dificile infected patients. The lesson here is that health-care workers should use protective gloves and fresh gloves with every patient.  Of course, glove use is not a substitute for proper hygiene – that means proper washing with soap and water…

Babies wage biological warfare on adults.

Infants can be colonized by toxin producing strains of Clostridium difficile but rarely develop disease. Infants and children could play a source in the spread of C. difficile disease to adults. http://jcm.asm.org/content/early/2013/10/24/JCM.01701-13.abstract http://www.asm.org/images/Communications/tips/2013/1113cdifficile.pdf Toxin-producing Clostridium difficile strains as long-term gut colonizers of healthy infants Clostridium difficile is a colonizer of the human gut, and toxin-producing…

Green Algae Chlorella for Immunity

  The green algea Chlorella, not to be confused with the disease cholera, has been found to increase salivary IgA, your first line of mucosal defense. Heavy exercise has been found to depress secretion of IgA. This paper reports that consumption of Chlorela attenuates that effect. Nutrition Journal 2012, 11:103 doi:10.1186/1475-2891-11-103 http://www.nutritionj.com/content/11/1/103/abstract Chlorella intake attenuates reduced salivary SIgA secretion in…