mtDNA deletions and age-related muscle loss

    Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age With age, somatically derived mitochondrial DNA (mtDNA) deletion mutations arise in many tissues and species. In skeletal muscle, deletion mutations clonally accumulate along the length of individual fibers. At high intrafiber abundances, these mutations disrupt individual cell respiration and are linked…

Exercise Improves Memory and Cognition

Yet another reason to avoid a sedentary lifestyle, even short-term exercise results in improvements to fitness, memory and cognition. Free from Frontiers in Aging Neuroscience http://www.frontiersin.org/Journal/10.3389/fnagi.2013.00075/abstract Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging Physical exercise, particularly aerobic exercise, is documented as providing a low cost regimen to counter well-documented cognitive…

Please Send Us Money So We Can Release Your Winnings

Why are elderly people frequent victims of implausible ‘get rich’ scams? This study suggests the elderly are less able to detect reward prediction errors – the difference between the predicted reward (what they are promised) and the actual reward (what they get). Young and old participants were given a gambling task to guess which of…

Intense Activity Linked to Better Cognitive Function in Elderly

Amount of physical activity has been correlated with higher cognitive function among the elderly. This study finds that intensity of activity not just amount is also important. I guess the lesson is don’t just go for a walk; Go for a fast walk. Translational Psychiatry (2012) 2, e191; doi:10.1038/tp.2012.118 http://www.nature.com/tp/journal/v2/n11/full/tp2012118a.html Intense physical activity is associated…