Eat your Jetlag?

Circadian rhythm influenced by meal timing.   Meal Timing Regulates the Human Circadian System Highlights A 5-hr delay in meal times changes the phase relationship of human circadian rhythms Plasma glucose, but not insulin or triglyceride, rhythms are delayed by late meals Adipose PER2 rhythms are delayed by late meals Rhythm changes occur without altered…

Default running pace is most efficient

People choose their most economic running pace, which of course is a problem when looking to lose weight. People choose to run at their optimal speed Objectives The purpose of this article is to test whether people choose to behave in a manner that reduces the amount of energy they use to travel a given distance.…

Science of cleaning your dirty laundry

“Come and whisper in my ear Give us dirty laundry Laundry hygiene—how to get more than clean Although laundering should mainly remove stains and dirt from used and worn textiles, the elimination of microbial contamination is an important aim of the laundry process as well. While industrial and institutional laundering employs standardized processes using high…

Diet rich in legumes lowers risk of diabetes

The saucy children’s rhyme tells us beans are good for your heart. There are other health benefits as well; higher consumption of legumes associated with lower risk of diabetes. Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study Background & aims Legumes, a low-energy, nutrient-dense and…

Go Nuts!

Daily consumption of a handful of nuts (28g) is associated with reduced risk of cancer, diabetes and cardiovascular disease.   Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies   Background Although nut consumption has been associated with a reduced risk of…

mtDNA deletions and age-related muscle loss

    Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age With age, somatically derived mitochondrial DNA (mtDNA) deletion mutations arise in many tissues and species. In skeletal muscle, deletion mutations clonally accumulate along the length of individual fibers. At high intrafiber abundances, these mutations disrupt individual cell respiration and are linked…

Wrapping Beta-cells in sugar-derivative makes them implantable

This is a really neat approach. Encapsulating beta cells (insulin producing cells) an alginate derivative makes them implantable without eliciting an immune response and normalizes glucose in mice.   Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice The transplantation of glucose-responsive, insulin-producing cells offers the potential for restoring glycemic control…