Low Level Pollution Can Drive Antibiotic Resistance

In short the paper raises the concern of low level of antibiotics and metals in polluted environments driving antibiotic resistance.

The first paper is a 1 page, non-technical commentary of the actual study, 2nd link.

[Personal Note: This is the 200th post]

Widening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients

and

 

Selection of a Multidrug Resistance Plasmid by Sublethal Levels of Antibiotics and Heavy Metals

Antibiotic resistance is in many pathogenic bacteria caused by genes that are carried on large conjugative plasmids. These plasmids typically contain multiple antibiotic resistance genes as well as genes that confer resistance to biocides and heavy metals. In this report, we show that very low concentrations of single antibiotics and heavy metals or combinations of compounds can select for a large plasmid that carries resistance to aminoglycosides, β-lactams, tetracycline, macrolides, trimethoprim, sulfonamide, silver, copper, and arsenic. Our findings suggest that the low levels of antibiotics and heavy metals present in polluted external environments and in treated animals and humans could allow for selection and enrichment of bacteria with multiresistance plasmids and thereby contribute to the emergence, maintenance, and transmission of antibiotic-resistant disease-causing bacteria.

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