Peachy Goodness. Peach Compounds Inhibit Tumour Growth

Peach Wikicommons: Lucien Monfils

A few years ago Noratto and others found peach extracts inhibited cancer cell growth in vitro. In this new study, they implanted breast cancer cells in mice. The mice were fed various amounts of peach extracts and they found it not only inhibited tumor growth but also metastasis.

The human equivalent is 2-3 peaches per day.

Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in vivo

The tumor growth inhibition and anti-metastatic effects of peach polyphenolics were investigated in vivo using a xenograft model and MDA-MB-435 breast cancer cells. Results showed that tumor growth and lung metastasis were inhibited in vivo by peach polyphenolics in a dose range of 0.8 – 1.6 mg/day and these effects were mediated by inhibition of metalloproteinases gene expression. Modulation of metalloproteinase-2 (MMP-2), metalloproteinase-3 (MMP-3) and metalloproteinase-13 (MMP-13) gene expression may be some the molecular targets for anti-metastatic activity of peach polyphenolics. Therefore, these compounds may constitute a novel chemopreventive tool to reduce the risk of metastasis in the combination therapy when primary cancer is diagnosed. Conversion to equivalent human intake for future clinical studies using the body surface area (BSA) normalization method gave a dose of ~370.6 mg/day for a human adult of 60 kg, which can be supplied by consuming 2 to 3 peach fruit per day or alternatively using a dietary supplement peach polyphenol extract powder.


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