During pregnancy a high fat diet negatively impacts the vascular system of the offspring.
International Journal of Obesity (2013) 37, 254–262; doi:10.1038/ijo.2012.42
Maternal high-fat diet impacts endothelial function in nonhuman primate offspring
The link between maternal under-nutrition and cardiovascular disease (CVD) in the offspring later in life is well recognized, but the impact of maternal over-nutrition on the offspring’s cardiovascular function and subsequent risk for CVD later in life remains unclear. Here, we investigated the impact of maternal exposure to a high-fat/calorie diet (HFD) during pregnancy and early postnatal period on endothelial function of the offspring in a nonhuman primate model.
Our data indicate that maternal HFD exposure impairs offspring’s endothelial function. Both early programming events and postweaning diet contribute to the abnormalities that could be reversed partially by diet intervention.