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Athletic Mice Have Bigger (mid) Brains

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These are not dumb jocks. Mice that have been selectively breed for voluntary running have larger midbrains. This supports a model that proposes sections of the brain can evolve independent of the rest of the brain.  Also see “Genetic architecture supports mosaic brain evolution and independent brain–body size regulation

See also http://jeb.biologists.org/content/216/3/iii.full

LARGER MIDBRAIN IN MICE MOTIVATED TO RUN doi: 10.1242/​jeb.084061

http://jeb.biologists.org/content/216/3/515

Mice selectively bred for high voluntary wheel running have larger midbrains: support for the mosaic model of brain evolution

Increased brain size, relative to body mass, is a primary characteristic distinguishing the mammalian lineage. This greater encephalization has come with increased behavioral complexity and, accordingly, it has been suggested that selection on behavioral traits has been a significant factor leading to the evolution of larger whole-brain mass. In addition, brains may evolve in a mosaic fashion, with functional components having some freedom to evolve independently from other components, irrespective of, or in addition to, changes in size of the whole brain. We tested whether long-term selective breeding for high voluntary wheel running in laboratory house mice results in changes in brain size, and whether those changes have occurred in a concerted or mosaic fashion. We measured wet and dry brain mass via dissections and brain volume with ex vivo magnetic resonance imaging of brains that distinguished the caudate-putamen, hippocampus, midbrain, cerebellum and forebrain. Adjusting for body mass as a covariate, mice from the four replicate high-runner (HR) lines had statistically larger non-cerebellar wet and dry brain masses than those from four non-selected control lines, with no differences in cerebellum wet or dry mass or volume. Moreover, the midbrain volume in HR mice was ~13% larger (P<0.05), while volumes of the caudate-putamen, hippocampus, cerebellum and forebrain did not differ statistically between HR and control lines. We hypothesize that the enlarged midbrain of HR mice is related to altered neurophysiological function in their dopaminergic system. To our knowledge, this is the first example in which selection for a particular mammalian behavior has been shown to result in a change in size of a specific brain region.

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Author: Caen Elegans, Ph.D.

Is a competitive dog trainer, endurance athlete, chess player and a young research scientist.

3 thoughts on “Athletic Mice Have Bigger (mid) Brains

  1. Yet another reason to exercise.
    –JW

  2. Pingback: Mice too clever for poison | Dear Kitty. Some blog

  3. Pingback: Baby We Were Born To Run | Animal Abstracts

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